A new study from Ontario, Canada, has raised serious questions about the safety of mRNA COVID-19 vaccines from Pfizer-BioNTech and Moderna. Dr. John Campbell recently reviewed the findings, which suggest that vaccine vials contain significant levels of residual DNA contamination far above established safety guidelines.
1. Excessive DNA contamination
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All tested vials of Pfizer and Moderna mRNA vaccines contained billions to hundreds of billions of DNA fragments per dose.
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The amounts were 36–627 times higher than the FDA/WHO regulatory limit of 10 ng per dose
2. Encapsulation in lipid nanoparticles (LNPs)
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Unlike “naked DNA,” the residual DNA was often found packaged inside LNPs.
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LNPs act like a Trojan horse, making DNA uptake into human cells much more efficient.
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This could increase the chances of DNA fragments entering cells and potentially the nucleus
3. Risk of cancer development
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DNA fragments might integrate into the human genome, causing mutations.
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Pfizer vials contained SV40 promoter-enhancer sequences, which can interfere with p53, the body’s key tumor-suppressor protein.
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This could weaken natural cancer defenses and increase cancer risk
4. Cumulative exposure risk
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Multiple doses (boosters) increase the cumulative DNA load in the body.
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Repeated exposure adds to the unquantified risk of DNA integration and potential long-term health effects
5. Unchanged contamination in newer versions
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Even the latest XBB.1.5 formulations showed no reduction in DNA residues compared to earlier versions
6. Manufacturing discrepancies
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Some vaccine lots used in clinical trials may have been manufactured differently than those released to the public.
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Raises concerns about informed consent and whether trial data fully reflected the risks of marketed products
7. Unmonitored long-term risks
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Potential consequences include:
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Cancer development (from DNA integration or SV40 effects)
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Genetic damage (from “shrapnel-like” billions of DNA fragments)
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Transfection of reproductive cells (sperm), raising hereditary concerns
- Dr. Campbell highlights the lack of monitoring or systematic study of these possible outcomes.
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✅ In short: The concerns center on high levels of residual DNA, its efficient delivery into cells via LNPs, the presence of SV40 promoter elements (Pfizer only), and the potential for mutations, cancer risk, and long-term effects such as negative reproductive impacts – people being made infertile or sterile – that remain unstudied.
What the Study Found
Researchers examined 32 vaccine vials from 16 different lots. Using two independent methods, they quantified the amount of residual plasmid DNA. That is genetic material left over from the manufacturing process.
The results showed that all products tested exceeded the U.S. FDA and World Health Organization’s recommended limit of 10 nanograms of DNA per dose.
Levels were found to be between 36 and 627 times higher than that threshold.
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Pfizer vials: 36–153 times above the limit
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Moderna vials: 112–627 times above the limit
Total DNA contamination ranged from 371–1,548 ng per dose in Pfizer vials and 1,130–6,280 ng per dose in Moderna vials. The recommended limit is 10. The actual contamination levels are outrageous – terrible!
In the United States there is an alarming rise in disability since the start of the CV-19 vaccines: USA Population – With a Disability, 16 Years and over
Labor Force Participation Rate – With a Disability, 16 to 64 Years, Women
Labor Force Participation Rate – With a Disability, 16 to 64 Years, Men
We don’t yet know the damage done to the reproductive systems – such as sperm mutations – in the young by these “vaccines”.
Encapsulation in Lipid Nanoparticles
One of the most troubling findings is that the DNA fragments are often encapsulated within lipid nanoparticles (LNPs). LNPs are the delivery system that carries the mRNA into human cells. When DNA is trapped inside these particles, it can enter cells far more efficiently than naked DNA, which raises the possibility of integration into the host genome.
This “Trojan horse” effect makes the old guidelines for DNA contamination, that were developed in the pre-LNP era, potentially outdated and insufficient.
The SV40 Promoter Concern
In addition to high levels of DNA, researchers detected fragments of the SV40 promoter-enhancer sequence in Pfizer vials. This sequence is known to interfere with the function of p53, one of the body’s most important tumor-suppressor proteins.
Disrupting p53 could make it more difficult for the body to stop abnormal cells from developing into cancer. Three Pfizer vials exceeded the regulatory guideline specifically for this SV40-related DNA.
Billions of DNA Fragments per Dose
The study estimated that each vaccine dose contained anywhere from hundreds of millions to hundreds of billions of DNA fragments. Most fragments were short – averaging around 200 base pairs in length – but some were as long as 3,500 base pairs.
Because of the sheer number of fragments and their delivery into cells via LNPs, the study authors suggest there could be long-term risks that remain unstudied.
Cumulative Exposure
Another issue raised is cumulative dosing. With multiple doses and boosters, the overall amount of DNA delivered into the body increases. This repeated exposure could amplify risks over time, but no systematic studies have been conducted to evaluate this.
No Improvement in New Formulations
Importantly, the most recent formulations, including those targeting the XBB.1.5 variant, still showed the presence of DNA residues. This indicates that manufacturers have not reduced contamination levels in newer vaccine versions.
Manufacturing Differences
The study also highlights that some vaccine batches used in clinical trials may have been manufactured differently from those released to the public. If true, trial safety data may not fully reflect the risks of the products actually administered. This raises concerns about informed consent.
Health Concerns Summarized
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Excessive DNA contamination – up to 627 times higher than official limits.
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Encapsulation in LNPs – DNA can more easily enter human cells.
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Cancer risk – SV40 promoter sequences found in Pfizer vials may interfere with tumor-suppressor proteins.
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Cumulative exposure – multiple doses raise unstudied long-term risks.
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No reduction in new versions – contamination levels remain in XBB.1.5 vials.
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Manufacturing discrepancies – possible differences between trial and commercial products.
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Unmonitored risks – potential for mutations, cancer development, and reproductive impacts has not been adequately studied.
Calls for Transparency and Oversight
Dr. Campbell emphasized that regulatory agencies and manufacturers must provide full transparency about the composition and manufacturing of these vaccines. He argues that current guidelines, designed before the advent of lipid nanoparticle delivery systems, are no longer adequate.
The study’s authors recommend adhering to the precautionary principle and conducting thorough safety evaluations. They stress the need for independent monitoring of long-term risks, particularly concerning cancer and reproductive health.
Final Thoughts
Whether or not this study leads to policy change, it raises fundamental questions about the safety framework used for mRNA vaccines. At the heart of the issue is trust: people deserve to know exactly what is in the products being injected into their bodies, how they are manufactured, and what risks – known or unknown – might accompany them.
